‘The second is nanopores, which can be our oldest line of analysis and which has now resulted in DNA sequencers depending on nanopores. We pull specific DNA strands via a nanopore and might then read through off the nucleotide sequence. Extremely not too long ago, we even managed to study out just one protein for the first time applying This system. But this line of investigation is not merely about creating tools, but also about serious Organic inquiries.
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‘It absolutely was only a issue of choosing up a book on mobile biology and starting to go through. I had originate from a planet of ultra-superior vacuums, cryostats and quantum phenomena, and now I used to be Operating at home temperature with molecular biology kits.
Sculpting nano-electrodes that has a transmission electron beam for electrical and geometrical characterization of nanoparticles.
That is a aspiration of mine and we established to work that has a delicious dose of naivety. That is a thing that will probably produce amazing leads to the extended time period, but that does not issue. You shouldn't only want to operate around the inquiries of tomorrow, but will also around the inquiries of your working day following tomorrow.’
Microbiology has only existed for a century, because we started to research micro-organisms a lot more significantly. I believed nanobiology was an correct time period, for the reason that all molecular Organic relevant interactions take place at the nanoscale: a protein is a few nanometres in size, DNA is 2 nm thick.’
‘Initially we looked at Organic systems using a Bodily perspective and acted on the basis in the instruments ceesdekker we knew. It took a couple of years in advance of we started Operating far more on the massive Organic issues. I then started to get in touch with it nanobiology, a expression that didn't exist at enough time.
2011, initially in vitro measurements of transportation throughout a single biomimetic nuclear pore complex; improvement of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the mechanism of homology recognition in DNA homologous recombination
2003, shown the primary biosensors created outside of a carbon nanotube; solved the structure and system of DNA repair proteins; and discovery of a different approach for fabricating solid-condition nanopores for DNA translocation
Bulk-surface area coupling identifies the mechanistic link involving Min-protein styles in vivo As well as in vitro
Testing pseudotopological and nontopological types for SMC-pushed DNA loop extrusion towards roadblock-traversal experiments
Nature Physics many thanks the anonymous reviewers for his or her contribution for the peer review of the operate.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij achieved enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent style and design in 2005. (nl)